Campral

Pronunciation: a-kam-PROE-sate
Generic Name: Acamprosate
Brand Name: Campral

Campral is used for:

Treating alcohol addiction by helping certain patients to avoid alcohol. Campral is used in combination with a treatment program that includes social support.

Campral is an anti-alcohol agent. It is thought to work by restoring the balance of certain chemicals in the brain of patients who have used large amounts of alcohol.

Do NOT use Campral if:

• you are allergic to any ingredient in Campral


• you have severe kidney problems

Contact your doctor or health care provider right away if any of these apply to you.

Before using Campral:

Some medical conditions may interact with Campral. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have kidney problems or a history of depression or suicidal thoughts or behaviors

Some MEDICINES MAY INTERACT with Campral. However, no specific interactions with Campral are known at this time.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Campral may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Campral:

Use Campral as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Campral may be taken with or without food.


• Swallow whole. Do not break, crush, or chew before swallowing.


• Continue to take Campral even if you feel well. Do not miss any doses.


• If you miss a dose of Campral, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Campral.

Important safety information:

• Campral may cause dizziness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Campral. Using Campral alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.


• Do not drink alcohol while you are using Campral. Continue taking Campral even if you begin drinking alcohol again. Discuss any drinking with your doctor.


• Alcohol-dependent patients should be monitored for the development of depression or suicidal thinking. Patients and their families or caregivers should pay close attention to changes in moods or actions, especially if changes occur suddenly. Contact your health care provider right away if any of the following effects occur or worsen: depression, anxiety, restlessness or irritability, panic attacks, thoughts or attempts of suicide, or other unusual changes in behavior or mood.


• Campral will not reduce or eliminate alcohol withdrawal symptoms. Discuss any questions or concerns with your doctor.


• Campral has been shown to help you avoid alcohol only in combination with a treatment program that includes counseling and support. Discuss treatment program options with your doctor.


• Use Campral with caution in the ELDERLY because they may be more sensitive to its effects.


• Use Campral with extreme caution in CHILDREN. Safety and effectiveness have not been confirmed.


• PREGNANCY and BREAST-FEEDING: If you become pregnant, discuss with your doctor the benefits and risks of using Campral during pregnancy. It is unknown if Campral is excreted in breast milk. If you are or will be breast-feeding while you are using Campral, check with your doctor or pharmacist to discuss the risks to your baby.

Possible side effects of Campral:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; dizziness; gas; loss of appetite; nausea; trouble sleeping; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); anxiety; behavior changes; depression; mental or mood changes; nervousness; panic attacks; restlessness; suicidal thoughts or behaviors.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Campral side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include diarrhea.

Proper storage of Campral:

Store Campral at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Campral out of the reach of children and away from pets.

General information:

• If you have any questions about Campral, please talk with your doctor, pharmacist, or other health care provider.


• Campral is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Campral. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Campral resources

• Campral Side Effects (in more detail)
• Campral Use in Pregnancy & Breastfeeding
• Drug Images
• Campral Support Group
• 51 Reviews for Campral - Add your own review/rating

• Campral Prescribing Information (FDA)


• Campral Monograph (AHFS DI)


• Campral Advanced Consumer (Micromedex) - Includes Dosage Information


• Campral Consumer Overview

Compare Campral with other medications

• Alcohol Dependence

amiloride

Generic Name: amiloride (a MIL o ride)

Brand Names: Midamor

What is amiloride?

Amiloride is a potassium-sparing diuretic (water pill) that prevents your body from absorbing too much salt and keeps your potassium levels from getting too low.

Amiloride is used to treat or prevent hypokalemia (low potassium levels in the blood).

Amiloride may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about amiloride?

Do not use this medication if you have kidney disease, urination problems, or high levels of potassium in your blood. Do not use potassium supplements or other diuretics while you are taking amiloride.

Before using this medication, tell your doctor if you have heart or liver disease, or a breathing disorder.

Avoid drinking alcohol, which can increase some of the side effects of amiloride.

Avoid a diet high in salt. Too much salt will cause your body to retain water and can make this medication less effective.

Do not use salt substitutes or low-sodium milk products that contain potassium. These products could cause your potassium levels to get too high while you are taking amiloride.

Avoid becoming overheated or dehydrated during exercise and in hot weather. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.

What should I discuss with my doctor before taking amiloride?

Do not use this medication if you have:

• kidney disease or are unable to urinate;


• 
  

  high potassium levels (hyperkalemia); or

  
  


• 
  

  if you are taking potassium supplements, or another potassium-sparing diuretic such Moduretic, spironolactone (Aldactone, Aldactazide), or triamterene (Dyrenium, Dyazide, Maxzide).

  
  

If you have certain conditions, you may need a dose adjustment or special tests to safely take this medication. Before using amiloride, tell your doctor if you have:

• 
  

  diabetes;

  
  


• 
  

  heart disease;

  
  


• 
  

  cirrhosis or other liver disease;

  
  


• 
  

  a breathing disorder; or

  
  


• 
  

  if you are using another diuretic.

  
  

FDA pregnancy category B. This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether amiloride passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I take amiloride?

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

Your doctor may occasionally change your dose to make sure you get the best results from this medication.

Take each dose with a full glass of water. Take amiloride with food.

To be sure this medication is not causing harmful effects, your blood will need to be tested on a regular basis. Your kidney function may also need to be tested. It is important that you not miss any scheduled visits to your doctor.

Amiloride can interfere with the results of a glucose tolerance test. Stop using this medication for at least 3 days before you have this test. Tell any doctor who treats you that you are using amiloride.

Store this medication at room temperature away from heat, light, and moisture. Do not allow the tablets to freeze.

See also: Amiloride dosage (in more detail)

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine.

Overdose symptoms may include dizziness, thirst, feeling light-headed, slow heartbeat, or fainting.

What should I avoid while taking amiloride?

Avoid drinking alcohol, which can increase some of the side effects of amiloride. Do not use salt substitutes or low-sodium milk products that contain potassium. These products could cause your potassium levels to get too high while you are taking amiloride.

Avoid a diet high in salt. Too much salt will cause your body to retain water and can make this medication less effective.

Avoid becoming overheated or dehydrated during exercise and in hot weather. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.

Amiloride side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using this medication and call your doctor at once if you have any of these serious side effects:

• 
  

  numbness or tingly feeling;

  
  


• 
  

  muscle pain or weakness;

  
  


• 
  

  slow, fast, or uneven heartbeat;

  
  


• 
  

  feeling drowsy, restless, or light-headed;

  
  


• 
  

  urinating less than usual or not at all;

  
  


• 
  

  dry mouth, increased thirst, tiredness, nausea, vomiting;

  
  


• 
  

  shallow breathing;

  
  


• 
  

  tremors, confusion; or

  
  


• 
  

  nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

  
  

Less serious side effects may include:

• 
  

  headache;

  
  


• 
  

  mild nausea, loss of appetite;

  
  


• 
  

  gas, stomach pain; or

  
  


• 
  

  skin rash.

  
  

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Amiloride Dosing Information

Usual Adult Dose for Ascites:

Initial dose: 5 mg orally once a day.
Maintenance dose: 5-10 mg once a day.

Usual Adult Dose for Congestive Heart Failure:

Initial dose: 5 mg orally once a day.
Maintenance dose: 5-10 mg once a day.

Usual Adult Dose for Edema:

Initial dose: 5 mg orally once a day.
Maintenance dose: 5-10 mg once a day.

Usual Adult Dose for Hypertension:

Initial dose: 5 mg orally once a day.
Maintenance dose: 5-10 mg once a day.

What other drugs will affect amiloride?

Before taking this medication, tell your doctor if you are using any of the following drugs:

• 
  

  cyclosporine (Neoral, Sandimmune, Gengraf);

  
  


• 
  

  tacrolimus (Prograf);

  
  


• 
  

  lithium;

  
  


• 
  

  an ACE inhibitor such as benazepril (Lotensin), captopril (Capoten), enalapril (Vasotec), lisinopril (Prinivil, Zestril), ramipril (Altace), and others; or

  
  


• 
  

  indomethacin or other NSAIDs (non-steroidal anti-inflammatory drugs) such as aspirin, ibuprofen (Motrin, Advil), diclofenac (Voltaren), naproxen (Aleve, Naprosyn), piroxicam (Feldene), nabumetone (Relafen), etodolac (Lodine), and others.

  
  

This list is not complete and there may be other drugs that can interact with amiloride. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

More amiloride resources

• Amiloride Side Effects (in more detail)
• Amiloride Dosage
• Amiloride Use in Pregnancy & Breastfeeding
• Drug Images
• Amiloride Drug Interactions
• Amiloride Support Group
• 2 Reviews for Amiloride - Add your own review/rating

• amiloride Advanced Consumer (Micromedex) - Includes Dosage Information


• Amiloride MedFacts Consumer Leaflet (Wolters Kluwer)


• Amiloride Prescribing Information (FDA)


• Amiloride Hydrochloride Monograph (AHFS DI)


• Midamor Prescribing Information (FDA)

Compare amiloride with other medications

• Ascites
• Edema
• Heart Failure
• High Blood Pressure

Where can I get more information?

• Your pharmacist can provide more information about amiloride.

See also: amiloride side effects (in more detail)

Utrogestan 100mg Capsules

1. Name Of The Medicinal Product

UTROGESTAN 100MG CAPSULES

2. Qualitative And Quantitative Composition

Each capsule contains 100 mg micronised progesterone (INN). For excipients, see 6.1.

3. Pharmaceutical Form

Capsules, soft

White

4. Clinical Particulars

4.1 Therapeutic Indications

Adjunctive use with estrogen in post-menopausal women with an intact uterus. (HRT)

4.2 Posology And Method Of Administration

Posology

In women receiving estrogen replacement therapy there is an increased risk of endometrial cancer which can be countered by progesterone administration. The recommended dose is 200 mg daily at bedtime, for twelve days in the last half of each therapeutic cycle (beginning on day 15 of the cycle and ending on day 26). Withdrawal bleeding may occur in the following week. Alternatively 100 mg can be given at bedtime from day 1 to day 25 of each therapeutic cycle, withdrawal bleeding being less with this treatment schedule.

Children: Not applicable.

Elderly: As for adults

Method of Administration: Oral. Utrogestan 100mg Capsules should not be taken with food

4.3 Contraindications

Known allergy or hypersensitivity to progesterone or to any of the excipients. The capsules contain arachis oil (peanut oil) and should never be used by patients allergic to peanuts. Severe hepatic dysfunction. Undiagnosed vaginal bleeding. Mammary or genital tract carcinoma. Thrombophlebitis. Thromboembolic disorders. Cerebral haemorrhage. Porphyria.

4.4 Special Warnings And Precautions For Use

Warnings:

Utrogestan 100mg Capsules are not a treatment for premature labour.

Prescription of progesterone beyond the first trimester of pregnancy may reveal gravidic cholestasis.

Utrogestan 100mg Capsules are not suitable for use as a contraceptive.

If unexplained, sudden or gradual, partial or complete loss of vision, proptosis or diplopia, papilloedema, retinal vascular lesions or migraine occur during therapy, the drug should be discontinued and appropriate diagnostic and therapeutic measures instituted.

Utrogestan 100mg Capsules are intended to be co-prescribed with an estrogen product as HRT. Epidemiological evidence suggests that the use of HRT is associated with an increased risk of developing deep vein thrombosis (DVT) or pulmonary embolism. The prescribing information for the co-prescribed estrogen product should be referred to for information about the risks of venous thromboembolism.

There is suggestive evidence of a small increased risk of breast cancer with estrogen replacement therapy. It is not known whether concurrent progesterone influences the risk of cancer in post-menopausal women taking hormone replacement therapy. The prescribing information for the co-prescribed estrogen product should be referred to for information about the risks of breast cancer.

Precautions

Prior to taking hormone replacement therapy (and at regular intervals thereafter) each woman should be assessed. A personal and family medical history should be taken and physical examination should be guided by this and by the contraindications and warnings for this product.

Utrogestan 100mg Capsules should not be taken with food and should be taken at bedtime. Concomitant food ingestion increases the bioavailability of Utrogestan 100mg Capsules.

Utrogestan 100mg Capsules should be used cautiously in patients with conditions that might be aggravated by fluid retention (e.g. hypertension, cardiac disease, renal disease, epilepsy, migraine, asthma); in patients with a history of depression, diabetes, mild to moderate hepatic dysfunction, migraine or photosensitivity and in breast-feeding mothers.

Clinical examination of the breasts and pelvic examination should be performed where clinically indicated rather than as a routine procedure. Women should be encouraged to participate in the national breast cancer screening programme (mammography) and the national cervical cancer screening programme (cervical cytology) as appropriate for their age. Breast awareness should also be encouraged and women advised to report any changes in their breasts to their doctor or nurse.

4.5 Interaction With Other Medicinal Products And Other Forms Of Interaction

Utrogestan 100mg Capsules may interfere with the effects of bromocriptine and may raise the plasma concentration of ciclosporin. Utrogestan 100mg Capsules may affect the results of laboratory tests of hepatic and/or endocrine functions.

Metabolism of Utrogestan 100mg Capsules is accelerated by rifamycin an antibacterial agent.

The metabolism of progesterone by human liver microsomes was inhibited by ketoconazole (IC₅₀ <0.1 μM Ketoconazole is a known inhibitor of cytochrome P450 3A4. These data therefore suggest that ketoconazole may increase the bioavailability of progesterone. The clinical relevance of the in vitro findings is unknown.

4.6 Pregnancy And Lactation

Pregnancy

Utrogestan 100mg Capsules are not indicated during pregnancy. If pregnancy occurs during medication, Utrogestan 100mg Capsules should be withdrawn immediately.

Lactation

Detectable amounts of progesterone enter the breast milk. There is no indication for prescribing HRT during lactation.

4.7 Effects On Ability To Drive And Use Machines

Utrogestan 100mg Capsules may cause drowsiness and/or dizziness in a minority of patients; therefore caution is advised in drivers and users of machines. Taking the capsules at bedtime should reduce these effects during the day.

4.8 Undesirable Effects

Somnolence or transient dizziness may occur 1 to 3 hours after intake of the drug. Bedtime dosing and reduction of the dose may reduce these effects.

Shortening of the cycle or breakthrough bleeding may occur. If this occurs, the dose of Utrogestan 100mg Capsules can be reduced and taken at bedtime from day 1 to day 26 of each therapeutic cycle.

Acne, urticaria, rashes, fluid retention, weight changes, gastro-intestinal disturbances, changes in libido, breast discomfort, premenstrual symptoms, menstrual disturbances; also chloasma, depression, pyrexia, insomnia, alopecia, hirsutism; rarely jaundice.

Venous thromboembolism, i.e. deep leg or pelvic venous thrombosis and pulmonary embolism, is more frequent among hormone replacement therapy users than among non-users.

4.9 Overdose

Symptoms of overdosage may include somnolence, dizziness, euphoria or dysmenorrhoea. Treatment is observation and, if necessary, symptomatic and supportive measures should be provided.

5. Pharmacological Properties

5.1 Pharmacodynamic Properties

Pharmacotherapeutic group (ATC code: G03D)

Progesterone is a natural progestogen, the main hormone of the corpus luteum and the placenta. It acts on the endometrium by converting the proliferating phase to the secretory phase. Utrogestan 100mg Capsules have all the properties of endogenous progesterone with induction of a full secretory endometrium and in particular gestagenic, antiestrogenic, slightly anti-androgenic and antialdosterone effects.

5.2 Pharmacokinetic Properties

Absorption

Micronised progesterone is absorbed by the digestive tract. Pharmacokinetic studies conducted in healthy volunteers have shown that after oral administration of 2 capsules (200mg), plasma progesterone levels increased to reach the Cmax of 13.8ng/ml +/- 2.9ng/ml in 2.2 +/- 1.4 hours. The elimination half-life observed was 16.8+/- 2.3 hours.

Although there were inter-individual variations, the individual pharmacokinetic characteristics were maintained over several months, indicating predictable responses to the drug.

Distribution

Progesterone is approximately 96%-99% bound to serum proteins, primarily to serum albumin (50%-54%) and transcortin (43%-48%).

Elimination

Urinary elimination is observed for 95% in the form of glycuroconjugated metabolites, mainly 3 α, 5 β–pregnanediol (pregnandiol).

Metabolism

Progesterone is metabolised primarily by the liver. The main plasma metabolites are 20 α hydroxy- Δ 4 α- prenolone and 5 α-dihydroprogesterone. Some progesterone metabolites are excreted in the bile and these may be deconjugated and further metabolised in the gut via reduction, dehydroxylation and epimerisation. The main plasma and urinary metabolites are similar to those found during the physiological secretion of the corpus luteum.

5.3 Preclinical Safety Data

Preclinical data revealed no special hazard for humans based on conventional studies of safety pharmacology and toxicity.

6. Pharmaceutical Particulars

6.1 List Of Excipients

Arachis oil

Soya lecithin

Gelatin

Glycerol

Titanium dioxide

6.2 Incompatibilities

None.

6.3 Shelf Life

3 years.

6.4 Special Precautions For Storage

No special precautions for storage.

6.5 Nature And Contents Of Container

The product is supplied in PVC/Aluminium blisters contained in cartons.

Pack size: 30 capsules

6.6 Special Precautions For Disposal And Other Handling

Not applicable.

7. Marketing Authorisation Holder

Laboratoires BESINS INTERNATIONAL

3, rue du Bourg l'Abbé

75003

Paris

France

8. Marketing Authorisation Number(S)

PL 16468/0001

9. Date Of First Authorisation/Renewal Of The Authorisation

10 January 2003

10. Date Of Revision Of The Text

Feburary 2006

Ichthyolee

Ichthyolee may be available in the countries listed below.

Ingredient matches for Ichthyolee

Ichthammol

Ichthammol is reported as an ingredient of Ichthyolee in the following countries:

• Turkey

International Drug Name Search

Xpect-AT Sustained-Release Tablets

Pronunciation: car-bay-ta-PEN-tane/gwye-FEN-e-sin
Generic Name: Carbetapentane/Guaifenesin
Brand Name: Examples include Allfen CX and Xpect-AT

Xpect-AT Sustained-Release Tablets are used for:

Relieving unproductive cough and reducing mucus in the chest due to colds, flu, or hay fever. It may also be used for other conditions as determined by your doctor.

Xpect-AT Sustained-Release Tablets are a cough suppressant and expectorant combination. The cough suppressant works in the brain to help decrease the cough reflex. The expectorant works by thinning mucus (phlegm) in the lungs, making it less sticky and easier to cough up. This makes coughs more productive.

Do NOT use Xpect-AT Sustained-Release Tablets if:

• you are allergic to any ingredient in Xpect-AT Sustained-Release Tablets


• the patient is a newborn or infant


• you have taken a monoamine oxidase inhibitor (MAOI) (eg, phenelzine) within the past 14 days

Contact your doctor or health care provider right away if any of these apply to you.

Before using Xpect-AT Sustained-Release Tablets:

Some medical conditions may interact with Xpect-AT Sustained-Release Tablets. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have chronic cough due to smoking, asthma, chronic bronchitis, or emphysema, or if your cough produces large amounts of mucus


• if you have a history of heart or blood vessel problems, high blood pressure, prostate problems, an overactive thyroid, diabetes, or glaucoma

Some MEDICINES MAY INTERACT with Xpect-AT Sustained-Release Tablets. Tell your health care provider if you are taking any other medicines, especially any of the following:

• MAOIs (eg, phenelzine) because the risk of their side effects may be increased by Xpect-AT Sustained-Release Tablets

This may not be a complete list of all interactions that may occur. Ask your health care provider if Xpect-AT Sustained-Release Tablets may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Xpect-AT Sustained-Release Tablets:

Use Xpect-AT Sustained-Release Tablets as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Xpect-AT Sustained-Release Tablets by mouth with or without food.


• Drinking extra fluids while you are taking Xpect-AT Sustained-Release Tablets are recommended. Check with your doctor for instructions.


• Swallow Xpect-AT Sustained-Release Tablets whole. Do not break, crush, or chew before swallowing. Some brands of Xpect-AT Sustained-Release Tablets may be broken in half before taking. If you have difficulty swallowing the whole tablet, ask your pharmacist if your brand of medicine may be broken in half.


• If you miss a dose of Xpect-AT Sustained-Release Tablets and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Xpect-AT Sustained-Release Tablets.

Important safety information:

• Xpect-AT Sustained-Release Tablets may cause drowsiness. This effect may be worse if you take it with alcohol or certain medicines. Use Xpect-AT Sustained-Release Tablets with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.


• Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Xpect-AT Sustained-Release Tablets; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.


• Do not use Xpect-AT Sustained-Release Tablets for a cough with a lot of mucous. Do not use it for a long-term cough (eg, caused by asthma, emphysema, smoking). However, you may use it for these conditions if your doctor tells you to.


• If cough persists for more than 1 week or is accompanied by a fever, contact your health care provider. A persistent cough could be a sign of a serious condition.


• Xpect-AT Sustained-Release Tablets should not be used in CHILDREN younger than 6 years old; safety and effectiveness in these children have not been confirmed.


• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Xpect-AT Sustained-Release Tablets while you are pregnant. It is not known if Xpect-AT Sustained-Release Tablets are found in breast milk. If you are or will be breast-feeding while you take Xpect-AT Sustained-Release Tablets, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Xpect-AT Sustained-Release Tablets:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Drowsiness; dry mouth, nose, or throat; upset stomach.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue).

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Xpect-AT side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include restlessness; seizures; severe agitation.

Proper storage of Xpect-AT Sustained-Release Tablets:

Store Xpect-AT Sustained-Release Tablets between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Xpect-AT Sustained-Release Tablets out of the reach of children and away from pets.

General information:

• If you have any questions about Xpect-AT Sustained-Release Tablets, please talk with your doctor, pharmacist, or other health care provider.


• Xpect-AT Sustained-Release Tablets are to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Xpect-AT Sustained-Release Tablets. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Xpect-AT resources

• Xpect-AT Side Effects (in more detail)
• Xpect-AT Use in Pregnancy & Breastfeeding
• Xpect-AT Drug Interactions
• Xpect-AT Support Group
• 0 Reviews for Xpect-AT - Add your own review/rating

Compare Xpect-AT with other medications

• Cough

Trilafon

Generic Name: perphenazine (per FEN a zeen)

Brand Names: Trilafon

What is Trilafon (perphenazine)?

Perphenazine is an anti-psychotic medication in a group of drugs called phenothiazines (FEEN-oh-THYE-a-zeens). It works by changing the actions of chemicals in your brain.

Perphenazine is used to treat psychotic disorders such as schizophrenia. It is also used to control severe nausea and vomiting.

Perphenazine may also be used for purposes not listed in this medication guide.

What is the most important information I should know about Trilafon (perphenazine)?

Stop using this medication and call your doctor at once if you have twitching or uncontrollable movements of your eyes, lips, tongue, face, arms, or legs. These could be early signs of dangerous side effects. Perphenazine is not for use in psychotic conditions related to dementia. Perphenazine may cause heart failure, sudden death, or pneumonia in older adults with dementia-related conditions. Do not use perphenazine if you have liver disease, brain damage, bone marrow depression, a blood cell disorder, or if you are also using large amounts of alcohol or medicines that make you sleepy. Do not use if you are allergic to perphenazine or other phenothiazines.

Before you take perphenazine, tell your doctor if you have severe depression, heart disease or high blood pressure, liver or kidney disease, severe asthma or breathing problems, history of seizures, Parkinson's disease, past or present breast cancer, adrenal gland tumor, enlarged prostate or urination problems, glaucoma, low levels of calcium in your blood, or if you have ever had serious side effects while using chlorpromazine or similar medicines.

Before taking perphenazine, tell your doctor about all other medications you use.

What should I discuss with my healthcare provider before taking Trilafon (perphenazine)?

Perphenazine is not for use in psychotic conditions related to dementia. Perphenazine may cause heart failure, sudden death, or pneumonia in older adults with dementia-related conditions. You should not use perphenazine if you have liver disease, brain damage, bone marrow depression, a blood cell disorder (such as low platelets or low red or white blood cell counts), or if you are also using large amounts of alcohol or medicines that make you sleepy. You also should not use this medication if you are allergic to perphenazine or other phenothiazines such as chlorpromazine (Thorazine), fluphenazine (Permitil), prochlorperazine (Compazine, Compro), promethazine (Adgan, Pentazine, Phenergan), thioridazine (Mellaril), or trifluoperazine (Stelazine).

If you have certain conditions, you may need a dose adjustment or special tests to safely use this medication. Before you take perphenazine, tell your doctor if you have:

• 
  

  severe or untreated depression;

  
  


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  heart disease or high blood pressure;

  
  


• liver or kidney disease;


• 
  

  severe asthma, emphysema, or other breathing problem;

  
  


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  a history of seizures;

  
  


• 
  

  Parkinson's disease;

  
  


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  past or present breast cancer;

  
  


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  adrenal gland tumor (pheochromocytoma);

  
  


• 
  

  enlarged prostate or urination problems;

  
  


• 
  

  low levels of calcium in your blood (hypocalcemia);

  
  


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  glaucoma; or

  
  


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  if you have ever had a serious side effect while using perphenazine or another phenothiazine.

  
  

Tell your doctor if you will be exposed to extreme heat or cold, or to insecticide poisons while you are taking perphenazine.

Tell your doctor if you are pregnant or plan to become pregnant while using this medication. Taking antipsychotic medication during the last 3 months of pregnancy may cause problems in the newborn, such as withdrawal symptoms, breathing problems, feeding problems, fussiness, tremors, and limp or stiff muscles. However, you may have withdrawal symptoms or other problems if you stop taking your medicine during pregnancy. If you become pregnant while taking perphenazine, do not stop taking it without your doctor's advice. Perphenazine can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Older adults may be more likely to have side effects from this medication.

How should I take Trilafon (perphenazine)?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results.

To be sure this medication is not causing harmful effects, your kidney and liver function may need to be tested. Visit your doctor regularly.

If you need surgery, tell the surgeon ahead of time that you are taking pherphenazine. Do not stop using perphenazine suddenly after long-term use, or you could have unpleasant withdrawal symptoms. Ask your doctor how to avoid withdrawal symptoms when you stop using perphenazine. Store at room temperature away from moisture, heat, and light.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include dry mouth, constipation, bloating or stomach cramps, extreme drowsiness, dizziness, fast or pounding heartbeat; uncontrollable muscle movements, fainting, and seizure (convulsions).

What should I avoid while taking Trilafon (perphenazine)?

This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall. Avoid drinking alcohol. It can increase some of the side effects of perphenazine. Avoid exposure to sunlight or tanning beds. Perphenazine can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.

Trilafon (perphenazine) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using perphenazine and call your doctor at once if you have a serious side effect such as:

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  twitching or uncontrollable movements of your eyes, lips, tongue, face, arms, or legs;

  
  


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  tremor (uncontrolled shaking), drooling, trouble swallowing, problems with balance or walking;

  
  


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  feeling restless, jittery, or agitated;

  
  


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  confusion, unusual thoughts or behavior;

  
  


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  feeling like you might pass out;

  
  


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  seizure (convulsions);

  
  


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  decreased night vision, tunnel vision, watery eyes, increased sensitivity to light;

  
  


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  nausea and stomach pain, skin rash, and jaundice (yellowing of the skin or eyes);

  
  


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  high fever, stiff muscles, confusion, sweating, fast or uneven heartbeats, rapid breathing;

  
  


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  pale skin, easy bruising or bleeding, fever, sore throat, flu symptoms;

  
  


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  urinating less than usual or not at all;

  
  


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  joint pain or swelling with fever, swollen glands, muscle aches, chest pain, vomiting, unusual thoughts or behavior, and patchy skin color; or

  
  


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  slow heart rate, weak pulse, fainting, slow breathing (breathing may stop).

  
  

Less serious side effects may include:

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  dizziness, drowsiness, anxiety;

  
  


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  blurred vision, headache;

  
  


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  sleep problems (insomnia), strange dreams;

  
  


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  constipation;

  
  


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  dry mouth or stuffy nose;

  
  


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  breast swelling or discharge;

  
  


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  changes in your menstrual periods;

  
  


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  weight gain, swelling in your hands or feet;

  
  


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  impotence, trouble having an orgasm; or

  
  


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  mild itching or skin rash.

  
  

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Trilafon (perphenazine)?

Cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression or anxiety can add to sleepiness caused by perphenazine. Tell your doctor if you regularly use any of these medicines, or any other antipsychotic medicine.

Also tell your doctor if you are taking any of the following medicines:

• 
  

  atropine (Atreza, Sal-Tropine);

  
  


• 
  

  lithium (Eskalith, Lithobid);

  
  


• 
  

  gefitinib (Iressa), imatinib (Gleevec), or nilotinib (Tasigna);

  
  


• 
  

  an antibiotic;

  
  


• 
  

  birth control pills or hormone replacement estrogens;

  
  


• 
  

  blood pressure medication;

  
  


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  a blood thinner such as warfarin (Coumadin, Jantoven);

  
  


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  certain asthma medications or bronchodilators;

  
  


• 
  

  heart rhythm medication;

  
  


• 
  

  HIV or AIDS medications;

  
  


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  incontinence medications;

  
  


• 
  

  insulin or diabetes medications you take by mouth;

  
  


• 
  

  medication for nausea, vomiting, or motion sickness;

  
  


• 
  

  medications to treat or prevent malaria;

  
  


• 
  

  medications used for general anesthesia;

  
  


• 
  

  medicines used to prevent organ transplant rejection;

  
  


• 
  

  numbing medicine such as lidocaine or Novocain;

  
  


• 
  

  a stimulant or ADHD medication;

  
  


• 
  

  ulcer or irritable bowel medications; or

  
  


• 
  

  medicines to treat Parkinson's disease, restless leg syndrome, or pituitary gland tumor (prolactinoma).

  
  

This list is not complete and there are many other medicines that can interact with perphenazine. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Keep a list with you of all the medicines you use and show this list to any doctor or other healthcare provider who treats you.

More Trilafon resources

• Trilafon Side Effects (in more detail)
• Trilafon Use in Pregnancy & Breastfeeding
• Drug Images
• Trilafon Drug Interactions
• Trilafon Support Group
• 3 Reviews for Trilafon - Add your own review/rating

• Perphenazine Prescribing Information (FDA)


• Perphenazine Professional Patient Advice (Wolters Kluwer)


• Perphenazine Monograph (AHFS DI)


• Perphenazine MedFacts Consumer Leaflet (Wolters Kluwer)

Compare Trilafon with other medications

• Bipolar Disorder
• Nausea/Vomiting
• Psychosis

Where can I get more information?

• Your pharmacist can provide more information about perphenazine.

See also: Trilafon side effects (in more detail)

Pepcid Oral Suspension

Pronunciation: fa-MOE-tih-deen
Generic Name: Famotidine
Brand Name: Pepcid Oral Suspension

Pepcid Oral Suspension is used for:

Treating and preventing ulcers. It is also used to treat conditions that cause increased acid secretion (eg, Zollinger-Ellison syndrome), gastroesophageal reflux disease (GERD), and esophagitis. It may also be used for other conditions as determined by your doctor.

Pepcid Oral Suspension is an H₂ (histamine) blocker. It works by reducing stomach acid by blocking one of the chemicals (histamine) that stimulates the release of acid into the stomach.

Do NOT use Pepcid Oral Suspension if:

• you are allergic to any ingredient in Pepcid Oral Suspension or to other H₂ blockers (eg, ranitidine)


• you are taking dasatinib

Contact your doctor or health care provider right away if any of these apply to you.

Before using Pepcid Oral Suspension:

Some medical conditions may interact with Pepcid Oral Suspension. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have kidney or liver problems.

Some MEDICINES MAY INTERACT with Pepcid Oral Suspension. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Dasatinib because its effectiveness may be decreased by Pepcid Oral Suspension

This may not be a complete list of all interactions that may occur. Ask your health care provider if Pepcid Oral Suspension may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Pepcid Oral Suspension:

Use Pepcid Oral Suspension as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Pepcid Oral Suspension by mouth with or without food.


• Shake well before each use.


• Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure this dose.


• If you take atazanavir, erlotinib, itraconazole, ketoconazole, or rilpivirine, ask your doctor or pharmacist how to take it with Pepcid Oral Suspension.


• Ask your doctor before taking antacids or other acid reducers with Pepcid Oral Suspension.


• If you miss a dose of Pepcid Oral Suspension, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Pepcid Oral Suspension.

Important safety information:

• Pepcid Oral Suspension may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Pepcid Oral Suspension with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.


• Notify your doctor if you have any symptoms of a bleeding ulcer, such as black, tarry stools, or vomit that looks like coffee grounds.


• You may need to make significant diet and lifestyle changes to help treat and prevent ulcers and other digestive problems, including stress-reduction programs, exercise, and diet changes.


• Use Pepcid Oral Suspension with caution in the ELDERLY; they may be more sensitive to its effects.


• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Pepcid Oral Suspension while you are pregnant. Pepcid Oral Suspension is found in breast milk. Do not breast-feed while taking Pepcid Oral Suspension.

Possible side effects of Pepcid Oral Suspension:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; diarrhea; dizziness; headache.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); irregular heartbeat; seizures.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Pepcid Oral side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of Pepcid Oral Suspension:

Store mixed suspension at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Do not freeze. Keep Pepcid Oral Suspension in original container. Do not store in the bathroom. Throw away unused suspension after 30 days. Keep Pepcid Oral Suspension out of the reach of children and away from pets.

General information:

• If you have any questions about Pepcid Oral Suspension, please talk with your doctor, pharmacist, or other health care provider.


• Pepcid Oral Suspension is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Pepcid Oral Suspension. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Pepcid Oral resources

• Pepcid Oral Side Effects (in more detail)
• Pepcid Oral Use in Pregnancy & Breastfeeding
• Pepcid Oral Drug Interactions
• Pepcid Oral Support Group
• 0 Reviews for Pepcid Oral - Add your own review/rating

Compare Pepcid Oral with other medications

• Duodenal Ulcer
• Duodenal Ulcer Prophylaxis
• Erosive Esophagitis
• GERD
• Indigestion
• Pathological Hypersecretory Conditions
• Peptic Ulcer
• Stomach Ulcer
• Upper GI Hemorrhage
• Urticaria
• Zollinger-Ellison Syndrome